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  Guillermo A Chacaltana

Guillermo A Chacaltana

Grad Student-Stone Lab, CB3

 

Physical & Biological Sciences Division

Chemistry & Biochemistry Department

Grad Student-Stone Lab, CB3

Graduate

Physical Sciences Building
459

Chemistry

Guillermo Chacaltana is a graduate student in the Stone lab at the University of California, Santa Cruz (UCSC) working under the guidance of Dr. Michael Stone. His research interests primarily focus on interrogating the relationship between ribonucleic acid structure and its role in biological function, particularly within the context of abnormal splicing in relation to disease. He is also interested in the relationship between telomeric nucleosomes and Shelterin, a multi-subunit protein complex responsible for the protection of telomeric ends, and how their cooperativity is established in maintaining chromosome stability. He earned his Bachelor’s degree in Biochemistry from the University of California, Berkeley.

 

Structural basis for pre-mRNA splicing, RNA therapeutics for rare human disease; molecular basis for nucleosome assembly and biochemisry.

RNA Biochemistry

Nucleosome Biochemistry

RNA Splicing

RNA chemical probing

Protein folding

UC-Doctoral Diversity Initiative Fellow

Graduate student leadership certificate program awardee

  • An intronic RNA element modulates Factor VIII exon-16 splicing. Victor Tse, Guillermo Chacaltana, Martin Gutierrez, Nicholas M. Forino, Arcelia G. Jimenez, Hanzhang Tao, Phong H. Do, Catherine Oh, Priyanka Chary, Isabel Quesada, Antonia Hamrick, Sophie Lee, Michael D. Stone, Jeremy R. Sanford Nucleic Acids Res. 2023 Nov 14.

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