Campus Directory

Division Physical & Biological Sciences Division

Department/College/Unit Chemistry & Biochemistry Department

Title Distinguished Professor and Department Chair
Department Chair

Affiliation Faculty

Other UCSC Campus Affiliation Biomolecular Science & Engineering

Faculty Type Regular Faculty

Areas of Expertise Chemistry
Biomedical Sciences
Biophysics
Biochemistry

Web Site

Primary Office Location Physical Sciences Building
256

Additional Location(s) Physical Sciences Bldg 256 (Office)
Physical Sciences Bldg 265 (Lab)

Office Hours by appointment

Mail Stop Chemistry

Biography, Education and Training

B.S., California State University, Los Angeles
Ph.D., Cornell University
Postdoc, Cornell University

Summary of Expertise

Electron paramagnetic resonance; nuclear magnetic resonance, protein structure, prion diseases

Research Interests

We use biophysical methods to study neurological proteins, their cofactors and how misregulation contributes to disease.

Awards, Honors and Grants

• 1986-88  National Institutes of Health Postdoctoral Fellow
• 1993  Van't Hoff Lectureship, Royal Netherlands Academy of Arts and Sciences
• 2002 UCSC Excellence in Teaching Award
• 2005  Commencement Keynote Speaker, Crown College
• 2010  Fellow, American Association for the Advancement of Science
• 2012  Silver Medal for Biology and Medicine, International EPR Society
• 2013  Distinguished Professor, Chemistry & Biochemistry
• 2016 UCSC Excellence in Teaching Award
• 2017-18 Division of Physical and Biological Sciences Outstanding Faculty Award 

Selected Publications

• Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X.  Cell September 2022
• Foley AR, Roseman GP, Chan K, Smart A, Finn TS, Yang K, Lokey RS, Millhauser GL, Raskatov JA.  Evidence for aggregation-independent, PrPC-mediated Aβ cellular internalization  Proc Natl Acad Sci USA  2020 117:28625-28631
• Robert Fairlie, Glenn Millhauser, Daniel Oliver and Randa Roland  The effects of male peers on the educational outcomes of female college students in STEM: Experimental evidence from partnerships in Chemistry courses PLoS One  2020 Jul 9;15(7):e0235383.
• Yu J, Gimenez LE, Hernandez CC, Wu Y, Wein AH, Han GW, McClary K, Mittal SR, Burdsall K, Stauch B, Wu L, Stevens SN, Peisley A, Williams SY, Chen V, Millhauser GL, Zhao S, Cone RD, Stevens RC. Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding. Science. 2020 368(6489):428-433.
• Schilling KM, Tao L, Wu B, Kiblen JTM, Ubilla-Rodriguez NC, Pushie MJ, Britt RD, Roseman GP, Harris DA, Millhauser GL. Both N-Terminal and C-Terminal Histidine Residues of the Prion Protein are Essential for Copper Coordination and Neuroprotective Self-Regulation. J Mol Biol. 2020 May 28:S0022-2836(20)30369-7
• Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA. The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Elife. 2017 May 2016.

Courses Chemistry 1A General Chemistry
Chemistry 1B General Chemistry
Chemistry 163A Physical Chemistry
Chemistry 163C Physical Chemistry
Chemistry 200B Proteins
Biochemistry 163B Biophysical Chemistry